A novel case of acute localized and generalized exanthematous pustulosis following IL-2 analogue injection amplified by immune checkpoint inhibition

By afschroeder • December 10, 2025

Johnsen NA, Carlisle R, Baghoomian W, Pierce JL, Nguyen MO. A novel case of acute localized and generalized exanthematous pustulosis following IL-2 analogue injection amplified by immune checkpoint inhibition. JAAD Case Rep. 2025 Oct 27;67:36-39. doi: 10.1016/j.jdcr.2025.10.025. PMID: 41362852; PMCID: PMC12681758.

Tags: acute generalized exanthematous pustulosis, acute localized exanthematous pustulosis, cutaneous immune-related adverse event, Dermatology, Drug reaction, drug-induced exanthem, immune checkpoint inhibitor, injection site reaction, pembrolizumab, Publications, pustules, Resident

Multi-cytokine based TWAS for seven inflammatory skin disorders identify candidate causal genes in keratinocytes

Zhang H, Patrick MT, Sarkar MK, Bogle R, Li Q, Uppala R, Perez White BE, Petukhova L, Dand N, Stuart PE, Christiano AM, Simpson MA,[...]

Increased risk of spontaneous abortion risk with alopecia areata independent of antiphospholipid syndrome and endometritis

Podolsky AS, Singal A, Goh C, Lipner SR. Increased risk of spontaneous abortion risk with alopecia areata independent of antiphospholipid syndrome and endometritis. J Am[...]

New insights into Rett syndrome pathogenesis: defining the role of MEPC2 in DNA damage

Mansooralavi N, Lowry WE. New insights into Rett syndrome pathogenesis: defining the role of MEPC2 in DNA damage. Front Neurol. 2026 May 11;17:1711771. doi: 10.3389/fneur.2026.1711771.[...]