Fidaxomicin reduces collagen expression in intestinal fibroblasts via platelet-derived growth factor receptor beta and glycogen synthase kinase-3 beta inhibition

By sjmartinez • May 22, 2025

Irwin S, van Daelen M, Almaraz I, Park R, Nelson B, Mahurkar-Joshi S, Rieder F, Shih DQ, Ho W, Limketkai B, Koon HW. Fidaxomicin reduces collagen expression in intestinal fibroblasts via platelet-derived growth factor receptor beta and glycogen synthase kinase-3 beta inhibition. Gastroenterology. 2025 May 19:S0016-5085(25)00765-6. doi: 10.1053/j.gastro.2025.04.028. Epub ahead of print. PMID: 40398622.

Tags: Digestive Diseases, fibrosis, high-throughput screening, Post Doc, protein array, Publications, receptor, spatial RNA sequencing

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