The ULK1-NCOA3 axis restrains de novo lipogenesis and prevents diet-induced steatohepatitis and fibrosis in mice

By afschroeder • April 3, 2026

Koo YD, Castillo RT, Sukumaran Nair A, Garneau M, Gochee C, Campbell ZV, Vakil TS, Ha J, Marti A, Soto J, Das D, Martinez-Lopez N, Sharma S, Delgado Y, Phung C, Ashley IA, Kapelczak ED, Jacobo R, Weatherford ET, Dai DF, Benhammou JN, Marshall AG, Hinton A Jr, Yang L, Pereira RO, TeSlaa T, Bouhaddou M, Singh R, Abel ED. The ULK1-NCOA3 axis restrains de novo lipogenesis and prevents diet-induced steatohepatitis and fibrosis in mice. J Clin Invest. 2026 Apr 2:e191101. doi: 10.1172/JCI191101. Epub ahead of print. PMID: 41926189.

Tags: Autophagy, cell biology, Digestive Diseases, Endocrinology, endocrinology, Hepatology, Obesity, Post Doc, Publications, Veterans Administration

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