Vitamin C reduces gastric pH in pharmacologically induced hypochlorhydria: a potential approach for mitigating pH-dependent drug-drug interactions of weak-base drugs

By sjmartinez • May 6, 2025

Fadda HM, Shin A, Waseem MR, Camilleri M. Vitamin C reduces gastric pH in pharmacologically induced hypochlorhydria: a potential approach for mitigating pH-dependent drug-drug interactions of weak-base drugs. J Pharm Sci. 2025 May 3:103809. doi: 10.1016/j.xphs.2025.103809. Epub ahead of print. PMID: 40324687.

Tags: Absorption, controlled release, Digestive Diseases, drug-drug interaction(s), duodenum, gastrointestinal tract, geriatric, pH, physicochemical properties, Publications, solubility, transit time

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