Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity

By sjmartinez • December 9, 2022

Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022 Dec 6;41(10):111775. doi: 10.1016/j.celrep.2022.111775. PMID: 36476855.

Tags: alpha-1 antitrypsin deficiency, cellular heterogeneity, CP: Metabolism, CP: Stem cell research, Endocrinology, ER stress, induced pluripotent stem cells, iPSC-derived hepatocytes, liver fibrosis, metabolic dysregulation, mitochondrial dysfunction, proteostasis, Publications, unfolded protein response

UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes

Chen HC, Bang MF, Wang HH, Shpargel KB, Kohn LA, Sailer D, Zhang S, McCarthy EC, Seyedsadr M, Stevens S, Pham CLH, Zhou Z, Yin[...]

Metabolic Acidosis in Chronic Alcoholism: When It’s Not Just Diabetic Ketoacidosis

Li R, Han J, Sidhu H. Metabolic Acidosis in Chronic Alcoholism: When It's Not Just Diabetic Ketoacidosis. Cureus. 2025 Nov 11;17(11):e96632. doi: 10.7759/cureus.96632. PMID: 41393585;[...]

Preliminary insights into methylation patterns in Agent Orange exposed thyroid cancers: a pilot study

Amreen B, Lesseur C, Sadikki H, Saul SR, Kazi S, Leung AM, Nguyen EY, Monaghan M, Taioli E, Genden EM, Chen J, van Gerwen M.[...]