Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity

By sjmartinez • December 9, 2022

Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022 Dec 6;41(10):111775. doi: 10.1016/j.celrep.2022.111775. PMID: 36476855.

Tags: alpha-1 antitrypsin deficiency, cellular heterogeneity, CP: Metabolism, CP: Stem cell research, Endocrinology, ER stress, induced pluripotent stem cells, iPSC-derived hepatocytes, liver fibrosis, metabolic dysregulation, mitochondrial dysfunction, proteostasis, Publications, unfolded protein response

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