Targeting lipidated amino acid deficiency mitigates fibrosis via a PPARα/CCL2 axis in metabolic dysfunction-associated steatohepatitis models

By afschroeder • September 25, 2026

Anand SK, Das S, Arias F, Richard KS, Rohilla S, Ghrayeb A, McKinney MP, Wang L, Tan L, Ding J, Kumar D, Pandey N, Lee J, Zhao Y, Mohajan S, Male G, Nunez K, Finney AC, Pearson-Gallion BH, Gade R, Maxie J, Liu Y, Kaur H, Pandit R, Ben Dhaou C, Eniafe J, Zhang X, Liu Z, Yurochko AD, Garcia-Barrio MT, Razani B, Chang F, Schopfer FJ, Huang X, Cai B, Gottlieb E, Wen B, Sun D, Liu W, Thevenot PT, Cohen AJ, Zhang J, Chen YE, Orr AW, Dhanesha N, Yurdagul A Jr, Rom O. Targeting lipidated amino acid deficiency mitigates fibrosis via a PPARα/CCL2 axis in metabolic dysfunction-associated steatohepatitis models. J Clin Invest. 2026 Sep 24:e204511. doi: 10.1172/JCI204511. Epub ahead of print. PMID: 42784330.

Tags: Amino acid metabolism, Digestive Diseases, fatty acid oxidation, fibrosis, Hematology/Oncology, Hepatology, Metabolism, Post Doc, Publications

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