Temporal multi-omic analysis uncovers sex-biased molecular programs underlying skeletal muscle adaptation to endurance training

By afschroeder • August 13, 2026

Many GM, Jin C, Day NJ, Iyer G, Smith G, Voos K, Sanford JA, Bareja A, Jimenez-Morales D, Leach DT, Sagendorf TJ, Ahmed A, Li X, Gaffrey MJ, Attah IK, Mitchell HD, Viggars MR, Gaul D, Huffman KM, Fernández F, Snyder MP, Ortlund E, Kohrt W, Wheeler MT, Kraus WE, Esser KA, Goodpaster BH, Goodyear LJ, Burant CF, Newgard CB, Hevener AL, Bodine SC, Qian WJ, Schenk S, Adkins JN, Lindholm ME; MoTrPAC study group. Temporal multi-omic analysis uncovers sex-biased molecular programs underlying skeletal muscle adaptation to endurance training. Cell Rep. 2026 Aug 12;45(8):117823. doi: 10.1016/j.celrep.2026.117823. Epub ahead of print. PMID: 42585023.

Tags: CP: Metabolism, cysteine oxidation, Endocrinology, endurance exercise, exercise training, mitochondrial remodeling, multi-omics, post-translational modifications, proteomics, PTMs, Publications, sex differences, Skeletal muscle

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