Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: four core genotypes and more

By afschroeder • February 22, 2026

Arnold AP, Chen X, Grzybowski MN, Ryan JM, Sengelaub DR, Mohanroy T, Furlan VA, Schmidtke HR, Prokop JW, Tutaj M, Ciosek JL, Kalbfleisch TS, O'Donnell L, Grisham W, Landen S, Malloy L, Takizawa A, Li K, Barseghyan H, Wiese CB, Vergnes L, Reue K, Wanagat J, Skaletsky H, Page DC, Harley VR, Dwinell MR, Geurts AM. Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: four core genotypes and more. Biol Sex Differ. 2026 Feb 21. doi: 10.1186/s13293-026-00837-5. Epub ahead of print. PMID: 41723549.

Tags: Four core genotypes, Gametogenesis, General Internal Medicine, Meiosis, Publications, Sex determination, Sex-chromosome effect, Sexual differentiation, Sry, Testis determination, Veterans Administration, X chromosome, Y chromosome

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