Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation

By afschroeder • January 28, 2026

Zhu C, Makita T, Lucero EY, Jyothidasan A, Patel R, Wang JJ, Cao Y, Rockman HA, Shivkumar K. Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation. JACC Clin Electrophysiol. 2026 Jan;12(1):44-58. doi: 10.1016/j.jacep.2025.08.016. Epub 2025 Oct 2. PMID: 41042183; PMCID: PMC12614344.

Tags: adrenergic signaling, Cardiology/Epi, denervation supersensitivity, neurocardiology, Publications, sympathetic nervous system, Ventricular arrhythmias

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