SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting

By afschroeder • January 9, 2026

Zhang Y, Silvestre-Roig C, Fu H, Alimohamadi H, Mandal T, Chen JW, Luo EW, Anda J, Linard Matos AL, Richter M, Mennella A, Lee H, Chan LC, Wang Y, Wang N, Wang H, Wang X, Lee CK, Ghosh S, Matsui T, Weiss TM, Guo T, Zhang M, Li D, Wolfgang MC, Hagan RS, Li MMH, Gunzer M, Sickmann A, Frasca L, Yeaman MR, Lande R, Cui Q, Soehnlein O, Wong GCL. SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting. Proc Natl Acad Sci U S A. 2026 Jan 13;123(2):e2521841122. doi: 10.1073/pnas.2521841122. Epub 2026 Jan 8. PMID: 41505524.

Tags: antimicrobial peptides, covid-19, Harbor UCLA, immune cell dysregulation, membrane elasticity theory, membrane permeation, Publications, Pulmonary, Critical Care & Sleep Medicine

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