Delivering guideline-directed medical therapy for heart failure with reduced ejection fraction as an over-encapsulated polypill: rationale and protocol for the COMBO-HF-X pilot crossover randomised clinical trial

By sjmartinez • March 22, 2025

DeJong C, Durstenfeld MS, Davis JD, Wang CS, Riley ED, Huffman MD, Hickey MD, Shade SB, Chen JC, Kazi DS, Grochowski J, Steward WT, Zier LS, Moreau N, Sandhu AT, Heidenreich PA, Agarwal A, Hsue PY. Delivering guideline-directed medical therapy for heart failure with reduced ejection fraction as an over-encapsulated polypill: rationale and protocol for the COMBO-HF-X pilot crossover randomised clinical trial. BMJ Open. 2025 Mar 21;15(3):e093663. doi: 10.1136/bmjopen-2024-093663. PMID: 40118491.

Tags: cardiology, Cardiology/Epi, heart failure, implementation science, Polypharmacy, Publications

Metabolomics-Based Investigation of PFOS-Induced Molecular Perturbations Across Multiple Rat Organs

Yen TH, Lee SH, Liang HJ, Huang ZX, Chen CT, Li C, Lin CY. Metabolomics-Based Investigation of PFOS-Induced Molecular Perturbations Across Multiple Rat Organs. Environ[...]

Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease

Ma J, Lai CQ, Li XS, Wang M, Wang Z, Yao J, Guo X, Taylor KD, Lee S, Tracy RP, Peter D, Liu Y, Rotter[...]

Transcatheter Pulmonary Valve Implantation With the Alterra Adaptive Prestent and SAPIEN 3 Transcatheter Heart Valve: 3-Year Pooled Outcomes of the ALTERRA Trials

Torres AJ, Dimas VV, Shahanavaz S, Balzer D, Morgan G, Lim DS, Armstrong AK, Berman D, Babaliaros V, Kim D, Gillespie MJ, Sommer R, Aboulhosn[...]