Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

By sjmartinez • July 12, 2024

Lee SHT, Garske KM, Arasu UT, Kar A, Miao Z, Alvarez M, Koka A, Darci-Maher N, Benhammou JN, Pan DZ, Örd T, Kaminska D, Männistö V, Heinonen S, Wabitsch M, Laakso M, Agopian VG, Pisegna JR, Pietiläinen KH, Pihlajamäki J, Kaikkonen MU, Pajukanta P. Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease. EBioMedicine. 2024 Jul 10;106:105232. doi: 10.1016/j.ebiom.2024.105232. Epub ahead of print. PMID: 38991381.

Tags: abdominal obesity, Cardiology/Epi, Colocalization, Digestive Diseases, eQTL, Expression quantitative trait loci, Genome-wide association study, GWAS, MASLD, Metabolic dysfunction-associated steatotic liver disease, Publications, Single-nucleus RNA-sequencing, snRNA-seq, Veterans Administration, Waist-hip ratio adjusted for body mass index, WHRadjBMI

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