Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR

By sjmartinez • February 1, 2024

Murugesan P, Zhang Y, Huang Y, Chengong Zong N, Youn JY, Chen W, Wang C, Loscalzo J, Cai H. Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR. Circ Res. 2024 Feb 1. doi: 10.1161/CIRCRESAHA.123.323090. Epub ahead of print. PMID: 38299369.

Tags: Cardiology/Epi, fibrinolytic agents, Hypertension, hypoxia, Publications, pulmonary, tetrahydrobiopterin, vasodilation

Prevalence, Progression, and Prognosis of Heart Stress In the Community: Implications for Heart Failure Prevention

Cai A, Liu L, Feng Y, Zhou Y, Li L, Bozkurt B, Januzzi JL, Lam CSP, Fonarow GC, Pandey A, Zhou Z, Cheng Y, Bayes-Genis[...]

Improved Assessment of Coronary Artery Disease in Obese Subjects with Flurpiridaz-18F PET Myocardial Perfusion Imaging: A Prespecified Subgroup Analysis of the AURORA Phase 3 Study

Patel KK, Maddahi J, Agostini D, Bax JJ, Beanlands RSB, Berman D, Dorbala S, Heller GV, Knuuti JM, Pelletier-Galarneau M, Tamaki N, Thompson D, Somer[...]

Massive Pulmonary Embolism Presenting as Recurrent Cardiac Arrest: Successful Resuscitation and Thrombolysis in a 74-Year-Old Male

Dave PR, Khan MZ, Higgins JR. Massive Pulmonary Embolism Presenting as Recurrent Cardiac Arrest: Successful Resuscitation and Thrombolysis in a 74-Year-Old Male. Cureus. 2026 Apr[...]