A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain-Inducing Nucleus Pulposus Cell Emergence

By afschroeder • July 10, 2026

Kaneda G, Wechsler JT, Chavez M, Sheyn J, Cheema K, Shen C, Rigo De Righi D, Wang L, Hsu YC, Avalos P, Xie Y, Tawackoli W, Floyd C, Li D, Sheyn D. A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain-Inducing Nucleus Pulposus Cell Emergence. JOR Spine. 2026 Jul 9;9(3):e70200. doi: 10.1002/jsp2.70200. PMID: 42428568; PMCID: PMC13347629.

Tags: biobehavioral tests, biomedical sciences, Cedars Sinai DoM, discogenic pain, General Internal Medicine, intervertebral disc degeneration, Low Back Pain, notochordal cells, nucleus pulposus, porcine model, Publications

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