Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor renewal in idiopathic pulmonary fibrosis

By afschroeder • May 8, 2026

Zhang X, Liu X, Qiao Y, Rabata A, Liu N, Yao C, Parimon T, Chen D, Hogaboam CM, Chen P, Stripp BR, Gardell SJ, Jiang D, Noble PW, Liang J. Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor renewal in idiopathic pulmonary fibrosis. J Clin Invest. 2026 May 7:e198031. doi: 10.1172/JCI198031. Epub ahead of print. PMID: 42096291.

Tags: Adult stem cells, Cedars Sinai DoM, cell biology, fibrosis, Metabolism, mitochondria, Publications, Pulmonary, Critical Care & Sleep Medicine, Pulmonology

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