Detecting clinically relevant topological structures in multiplexed spatial proteomics using TopKAT

By afschroeder • January 27, 2026

Samorodnitsky S, Campbell K, Little A, Ling W, Zhao N, Chen YC, Wu MC. Detecting clinically relevant topological structures in multiplexed spatial proteomics using TopKAT. Patterns (N Y). 2026 Jan 9;7(1):101456. doi: 10.1016/j.patter.2025.101456. PMID: 41583981; PMCID: PMC12827733.

Tags: cell-level imaging, Hematology/Oncology, kernel association testing, kernel machine regression, multiplexed spatial proteomics, persistent homology, Publications, topological data analysis, tumor microenvironment

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