CD146+ pericyte-like lung cancer brain metastatic stem cells promote tumor angiogenesis through dual regulatory effects on the VEGF/VEGFR axis

By afschroeder • December 9, 2025

Liu W, Duan W, Xia S, Liu Y, Chu H, Liang K, Fang S, Lin M, Wei S, You X, Hu Q, Qi J, Wang Q. CD146⁺pericyte-like lung cancer brain metastatic stem cells promote tumor angiogenesis through dual regulatory effects on the VEGF/VEGFR axis. Theranostics. 2026 Jan 1;16(4):1905-1924. doi: 10.7150/thno.122241. PMID: 41356185; PMCID: PMC12680595.

Tags: Angiogenesis, anti-vascular therapy, cancer stem cell, CD146, Hematology/Oncology, lung cancer brain metastasis, Publications, tumor microenvironment

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