Akebia Saponin D Targeting Ubiquitin Carboxyl-Terminal Hydrolase 4 Promotes Peroxisome Proliferator-Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity

By afschroeder • October 17, 2025

Chen L, Liu DH, Li YX, Yang S, Jia WH, Peng L, Liu HL, Wang XB, Hu B, Wang YC, Pan C, Lusis AJ, Liu LH, Gong LL. Akebia Saponin D Targeting Ubiquitin Carboxyl-Terminal Hydrolase 4 Promotes Peroxisome Proliferator-Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity. MedComm (2020). 2025 Oct 15;6(11):e70420. doi: 10.1002/mco2.70420. PMID: 41104164; PMCID: PMC12521790.

Tags: Akebia Saponin D, Cardiology/Epi, deubiquitination, mitochondria, Obesity, Publications, ubiquitin carboxyl‐terminal hydrolase 4

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