Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells

By afschroeder • August 31, 2025

Li YR, Hu J, Li Z, Zhu E, Chen Y, Halladay T, Shen X, Fang Y, Zhu Y, Lyu Z, Tian Y, Huang J, Zhao AS, Ma NY, Zhang C, Xie Y, Zhang H, Hsiai T, Chin AI, Wu L, Yang L. Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells. Cell Rep Med. 2025 Aug 27:102321. doi: 10.1016/j.xcrm.2025.102321. Epub ahead of print. PMID: 40885188.

Tags: alloreactive T cell, allorejection, CAR-NKT cell, Cardiology/Epi, CD70, hematopoietic stem and progenitor cell, HSPC, invariant natural killer T cell, multimodal targeting, NKT cell, patient-derived xenograft model, PDX, Publications, RCC, Renal cell carcinoma, TME, tumor microenvironment, Veterans Administration

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