The protein deacetylase SIRT2 exerts metabolic control over adaptive Beta cell proliferation

By afschroeder • August 6, 2025

Wortham M, Ramms B, Zeng C, Benthuysen JR, Sai S, Pollow DP, Liu F, Schlichting M, Harrington AR, Liu B, Prakash TP, Pirie EC, Zhu H, Baghdasarian S, Lee ST, Ruthig VA, Wells KL, Auwerx J, Shirihai OS, Sander M. The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation. J Clin Invest. 2025 Jul 31:e187020. doi: 10.1172/JCI187020. Epub ahead of print. PMID: 40762838.

Tags: beta cells, diabetes, Endocrinology, endocrinology, Metabolism, mitochondria, Publications

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