A call for transparency, improved reporting, and interpretation of trials using surrogate end points in cardiac electrophysiology

By afschroeder • August 3, 2025

Tereshchenko LG, Manyara AM, Ciani O, Sodeke SO, Bradford CN, Santangeli P, Kapadia SR, Wazni O, Narayan SM, Chugh SS, Bilchick K, Huizar JF, Vaseghi M, Chung MK, Ellenbogen KA, Taylor RS. A call for transparency, improved reporting, and interpretation of trials using surrogate end points in cardiac electrophysiology. Heart Rhythm. 2025 Aug;22(8):e492-e499. doi: 10.1016/j.hrthm.2025.02.038. Epub 2025 Feb 26. PMID: 40021073; PMCID: PMC12317828.

Tags: Biomarker, Cardiology/Epi, Cedars Sinai DoM, Checklist, Clinical Trial, Outcome, Publications, Randomized Controlled Trial, Research design, standards, Surrogate end point, surrogate marker

Metabolomics-Based Investigation of PFOS-Induced Molecular Perturbations Across Multiple Rat Organs

Yen TH, Lee SH, Liang HJ, Huang ZX, Chen CT, Li C, Lin CY. Metabolomics-Based Investigation of PFOS-Induced Molecular Perturbations Across Multiple Rat Organs. Environ[...]

Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease

Ma J, Lai CQ, Li XS, Wang M, Wang Z, Yao J, Guo X, Taylor KD, Lee S, Tracy RP, Peter D, Liu Y, Rotter[...]

Transcatheter Pulmonary Valve Implantation With the Alterra Adaptive Prestent and SAPIEN 3 Transcatheter Heart Valve: 3-Year Pooled Outcomes of the ALTERRA Trials

Torres AJ, Dimas VV, Shahanavaz S, Balzer D, Morgan G, Lim DS, Armstrong AK, Berman D, Babaliaros V, Kim D, Gillespie MJ, Sommer R, Aboulhosn[...]