Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

By sjmartinez • May 23, 2025

Li B, Elsten-Brown J, Li M, Zhu E, Li Z, Chen Y, Kang E, Ma F, Chiang J, Li YR, Zhu Y, Huang J, Fung A, Scarborough Q, Cadd R, Zhou JJ, Chin AI, Pellegrini M, Yang L. Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis. Cell. 2025 May 20:S0092-8674(25)00502-1. doi: 10.1016/j.cell.2025.04.032. Epub ahead of print. PMID: 40403728.

Tags: antidepressants, cancer immunotherapy, Cardiology/Epi, Dermatology, immune checkpoint, intratumoral serotonin axis, PD-1 blockade, Publications, serotonin, serotonin transporter, SSRIs, T cell antitumor immunity, tumor microenvironment, Veterans Administration

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