Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

By sjmartinez • May 23, 2025

Li B, Elsten-Brown J, Li M, Zhu E, Li Z, Chen Y, Kang E, Ma F, Chiang J, Li YR, Zhu Y, Huang J, Fung A, Scarborough Q, Cadd R, Zhou JJ, Chin AI, Pellegrini M, Yang L. Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis. Cell. 2025 May 20:S0092-8674(25)00502-1. doi: 10.1016/j.cell.2025.04.032. Epub ahead of print. PMID: 40403728.

Tags: antidepressants, cancer immunotherapy, Cardiology/Epi, Dermatology, immune checkpoint, intratumoral serotonin axis, PD-1 blockade, Publications, serotonin, serotonin transporter, SSRIs, T cell antitumor immunity, tumor microenvironment, Veterans Administration

A deep learning phenome wide association study of the electrocardiogram

Hughes JW, Theurer J, Vukadinovic M, Rogers AJ, Somani S, Kang G, Ghazizadeh Z, O'Sullivan JW, Jain SS, Gomes B, Salerno M, Ashley E, Zou[...]

Novel insights into post-myocardial infarction cardiac remodeling through algorithmic detection of cell-type composition shifts

Gural B, Kirkland L, Hockett A, Sandroni P, Zhang J, Rosa-Garrido M, Swift SK, Chapski DJ, Flinn MA, O'Meara CC, Vondriska TM, Patterson M, Jensen[...]

The accumulation of progerin underlies the loss of aortic smooth muscle cells in Hutchinson-Gilford progeria syndrome

Kim PH, Kim JR, Heizer PJ, Jung H, Tu Y, Presnell A, Scheithauer J, Yu RG, Young SG, Fong LG. The accumulation of progerin underlies[...]