Single-cell Profiling of Prurigo Nodularis Demonstrates Immune-Stromal Crosstalk Driving Profibrotic Responses and Reversal with Nemolizumab

By sjmartinez • July 29, 2023

Ma F, Gharaee-Kermani M, Tsoi LC, Plazyo O, Chaskar P, Harms P, Patrick MT, Xing X, Hile G, Piketty C, Lazzari A, Van Delm W, Maverakis E, Nakamura M, Modlin RL, Kahlenberg JM, Billi AC, Julia V, Krishnaswamy JK, Gudjonsson JE. Single-cell Profiling of Prurigo Nodularis Demonstrates Immune-Stromal Crosstalk Driving Profibrotic Responses and Reversal with Nemolizumab. J Allergy Clin Immunol. 2023 Jul 26:S0091-6749(23)00925-9. doi: 10.1016/j.jaci.2023.07.005. Epub ahead of print. PMID: 37506977.

Tags: Dermatology, fibrosis, Inflammation, nemolizumab, Prurigo nodularis, Publications, single-cell RNA-sequencing, spatial-sequencing

Safety and Efficacy of envudeucitinib, a highly selective, oral allosteric TYK2 inhibitor, in patients with moderate-to-severe plaque psoriasis: Results from the 52-week open-label extension period of the Phase 2 STRIDE study

Papp KA, Jacobs S, Sofen H, Bukhalo M, Muscianisi E, Ma G, Lau G, Bettinger M, Rubio RG, Hitraya E, Blauvelt A; Open-Label Extension study[...]

Differentially Expressed Salivary miRNAs in Temporomandibular Disorders

Kaczor-Urbanowicz KE, Aziz M, Wilhalme H, Aronovich S, Hatfield ER, Aghaloo T, Arman S, Mohammadi A, Husain M, Tetradis S, Elashoff D, Pellegrini M, Wong[...]

Neurotrophic Tyrosine Receptor Kinase-Rearranged Spindle Cell Neoplasm Presenting on the Breast of a 44-Year-Old Woman

Saka F, McKenzie S, Milani-Nejad N, Smart C. Neurotrophic Tyrosine Receptor Kinase-Rearranged Spindle Cell Neoplasm Presenting on the Breast of a 44-Year-Old Woman. Am J[...]