Lipophilic statins inhibit YAP co-activator transcriptional activity in HCC cells through Rho-mediated modulation of the actin cytoskeleton

By sjmartinez • June 28, 2023

Benhammou JN, Qiao B, Ko A, Sinnett-Smith J, Pisegna J, Rozengurt E. Lipophilic statins inhibit YAP co-activator transcriptional activity in HCC cells through Rho-mediated modulation of the actin cytoskeleton. Am J Physiol Gastrointest Liver Physiol. 2023 Jun 27. doi: 10.1152/ajpgi.00089.2023. Epub ahead of print. PMID: 37366601.

Tags: chemoprevention, Digestive Diseases, Hepatocellular carcinoma, Publications, Statins, Veterans Administration, YAP

Biogeographical distribution of gut microbiome composition and function is partially recapitulated by fecal transplantation into germ-free mice

Yang JC, Lagishetty V, Aja E, Arias-Jayo N, Chang C, Hauer M, Katzka W, Zhou Y, Sedighian F, Koletic C, Liang F, Dong TS, Situ[...]

Extended flexible sigmoidoscopy using water exchange facilitates a complete colon examination without sedation in participants undergoing average risk colorectal cancer screening: results from a randomized trial

Bak A, Parker B, Perini R, Aulakh A, Oliveira C, Richardson W, Hirschkorn P, Sullivan B, Recsky M, Orlando T, Leung F. Extended flexible sigmoidoscopy[...]

Genome-Wide DNA Methylation Identifies Potential Disease-Specific Biomarkers and Pathophysiologic Mechanisms in Irritable Bowel Syndrome, Inflammatory Bowel Disease, and Celiac Disease

Mahurkar-Joshi S, Thompson M, Villarruel E, Lewis JD, Lin LD, Farid M, Nayeb-Hashemi H, Storage T, Weiss GA, Limketkai BN, Sauk JS, Mayer EA, Chang[...]