Differentiating between liver diseases by applying multiclass machine learning approaches to transcriptomics of liver tissue or blood-based samples

By sjmartinez • September 18, 2022

Listopad S, Magnan C, Asghar A, Stolz A, Tayek JA, Liu ZX, Morgan TR, Norden-Krichmar TM. Differentiating between liver diseases by applying multiclass machine learning approaches to transcriptomics of liver tissue or blood-based samples. JHEP Rep. 2022 Aug 18;4(10):100560. doi: 10.1016/j.jhepr.2022.100560. PMID: 36119721; PMCID: PMC9472076.

AC, alcohol-associated cirrhosis, AH, alcohol-associated hepatitis, AKR1B10, aldo-keto reductase family 1 member B10, BTM, blood transcription module, Classification, DE, differential expression, FPKM, fragments per kilobase of exon model per million reads mapped, GSEA, gene set-enrichment analysis, IG, information gain, IPA, Ingenuity Pathway Analysis, LR, logistic regression, LTCDS, liver tissue cell distribution system, LV, liver tissue, ML, machine learning, MMP, matrix metalloproteases, NAFLD, non-alcohol-associated fatty liver disease, PBMCs, peripheral blood mononuclear cells, RNA sequencing, RNA-seq, RNA sequencing, SCAHC, Southern California Alcoholic Hepatitis Consortium, SVM, support vector machine, TNF, tumor necrosis factor, alcohol-associated liver disease, biomarker discovery, kNN, k-nearest neighbors,

Tags: AC, AH, AKR1B10, alcohol-associated cirrhosis, alcohol-associated hepatitis, alcohol-associated liver disease, aldo-keto reductase family 1 member B10, biomarker discovery, blood transcription module, BTM, classification, DE, differential expression, FPKM, fragments per kilobase of exon model per million reads mapped, gene set-enrichment analysis, GSEA, Harbor UCLA, IG, information gain, Ingenuity Pathway Analysis, IPA, k-nearest neighbors, kNN, liver tissue, liver tissue cell distribution system, logistic regression, LR, LTCDS, LV, machine learning, matrix metalloproteases, ML, MMP, NAFLD, non-alcohol-associated fatty liver disease, PBMCs, peripheral blood mononuclear cells, Publications, RNA sequencing, RNA-seq, SCAHC, Southern California Alcoholic Hepatitis Consortium, support vector machine, SVM, TNF, tumor necrosis factor

Cefadroxil as Oral Transitional Therapy for Gram-Positive Bacteremia With or Without Non-Vertebral Osteomyelitis: A Multicenter Retrospective Cohort Study

Clark DC, Baden R, Banerjee J, Bedrossian R, Chute H, Davar K, Deng D, Donnelly M, Fernandez D, Goodman R, Gordon H, Harris E, Hutcheon[...]

Renal Outcomes of Triglyceride-Targeting Lipid-Lowering Therapies versus Statins in Patients with CKD

Naim MAAZ, Thomas F, Streja E, Davis RL, Kalantar-Zadeh K, Sumida K, Kovesdy CP. Renal Outcomes of Triglyceride-Targeting Lipid-Lowering Therapies versus Statins in Patients with[...]

A Review of Randomized Controlled Trials for Vitiligo Therapies Published Between 2013 and 2023

Maverakis Ramirez N, Jaeger ZJ, Lee DJ. A Review of Randomized Controlled Trials for Vitiligo Therapies Published Between 2013 and 2023. Cureus. 2026 Jul 8;18(7):e112280.[...]