Differentiating between liver diseases by applying multiclass machine learning approaches to transcriptomics of liver tissue or blood-based samples

By sjmartinez • September 18, 2022

Listopad S, Magnan C, Asghar A, Stolz A, Tayek JA, Liu ZX, Morgan TR, Norden-Krichmar TM. Differentiating between liver diseases by applying multiclass machine learning approaches to transcriptomics of liver tissue or blood-based samples. JHEP Rep. 2022 Aug 18;4(10):100560. doi: 10.1016/j.jhepr.2022.100560. PMID: 36119721; PMCID: PMC9472076.

AC, alcohol-associated cirrhosis, AH, alcohol-associated hepatitis, AKR1B10, aldo-keto reductase family 1 member B10, BTM, blood transcription module, Classification, DE, differential expression, FPKM, fragments per kilobase of exon model per million reads mapped, GSEA, gene set-enrichment analysis, IG, information gain, IPA, Ingenuity Pathway Analysis, LR, logistic regression, LTCDS, liver tissue cell distribution system, LV, liver tissue, ML, machine learning, MMP, matrix metalloproteases, NAFLD, non-alcohol-associated fatty liver disease, PBMCs, peripheral blood mononuclear cells, RNA sequencing, RNA-seq, RNA sequencing, SCAHC, Southern California Alcoholic Hepatitis Consortium, SVM, support vector machine, TNF, tumor necrosis factor, alcohol-associated liver disease, biomarker discovery, kNN, k-nearest neighbors,

Tags: AC, AH, AKR1B10, alcohol-associated cirrhosis, alcohol-associated hepatitis, alcohol-associated liver disease, aldo-keto reductase family 1 member B10, biomarker discovery, blood transcription module, BTM, classification, DE, differential expression, FPKM, fragments per kilobase of exon model per million reads mapped, gene set-enrichment analysis, GSEA, Harbor UCLA, IG, information gain, Ingenuity Pathway Analysis, IPA, k-nearest neighbors, kNN, liver tissue, liver tissue cell distribution system, logistic regression, LR, LTCDS, LV, machine learning, matrix metalloproteases, ML, MMP, NAFLD, non-alcohol-associated fatty liver disease, PBMCs, peripheral blood mononuclear cells, Publications, RNA sequencing, RNA-seq, SCAHC, Southern California Alcoholic Hepatitis Consortium, support vector machine, SVM, TNF, tumor necrosis factor

In Silico Design of a Multiepitope Vaccine Against Intestinal Pathogenic Escherichia coli Based on the 2011 German O104:H4 Outbreak Strain Using Reverse Vaccinology and an Immunoinformatic Approach

Youssef EG, Elnesr K, Hanora A. In Silico Design of a Multiepitope Vaccine Against Intestinal Pathogenic Escherichia coli Based on the 2011 German O104:H4 Outbreak Strain Using[...]

Effect of High Altitude on Small Pulmonary Vein and Artery Volume in the COPDGene Cohort: Towards Better Understanding of Lung Physiology and Pulmonary Disease

Kwee AKAL, Pompe E, Gallardo Estrella L, Charbonnier JP, Humphries SM, Tiddens HAWM, Crapo JD, Casaburi R, de Jong PA, Lynch DA, Mohamed Hoesein FAA.[...]

The Association of Niacin Use with Kidney Outcomes and Mortality

Takahashi R, Bui TA, Elali I, Tran D, Sumida K, Thomas F, Dukkipati R, Shah A, Rhee CM, Kovesdy CP, Kalantar-Zadeh K, Takahashi R. The[...]