The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR

By sjmartinez • August 5, 2022

Steffen J, Ngo J, Wang SP, Williams K, Kramer HF, Ho G, Rodriguez C, Yekkala K, Amuzie C, Bialecki R, Norquay L, Nawrocki AR, Erion M, Pocai A, Shirihai OS, Liesa M. The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR. Mol Metab. 2022 Aug 5:101566. doi: 10.1016/j.molmet.2022.101566. Epub ahead of print. PMID: 35940556.

Tags: ATF4, Drp1, Endocrinology, ISR, mitochondria, NASH, Oma1, Publications

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