Combination of genetic eNOS deficiency and high-fat diet induces reproducible cardiometabolic HFpEF

By afschroeder • September 16, 2026

Elbatreek MH, Khodade V, Amin D, Huerta M, Allerton TD, Polhemus DJ, Shah SJ, Vondriska TM, Goodchild TT, Lefer DJ. Combination of genetic eNOS deficiency and high-fat diet induces reproducible cardiometabolic HFpEF. Redox Biol. 2026 Sep 11;97:104394. doi: 10.1016/j.redox.2026.104394. Epub ahead of print. PMID: 42743759.

Tags: animal model, Cardiology/Epi, eNOS, HFPEF, high-fat diet, Organ fibrosis exercise intolerance, Publications, tirzepatide

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