SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

Yao Z, Alvarez PA, Chavez C, Delgado Y, Kaushal P, Buchholz DW, Austin D, Li Q, Yu Y, Zaiss AK, Arumugaswami V, Ding Q, Hsu JJ, Damoiseaux R, Aguilar HC, Bouhaddou M, Hoffmann A, Li MMH. SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages. Sci Adv. 2026 Aug 7;12(32):eaea2780. doi: 10.1126/sciadv.aea2780. Epub 2026 Aug 5. PMID: 42555728; PMCID: PMC13440407.


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