Delivering Quadruple Therapy for Heart Failure With Reduced Ejection Fraction in a Customizable Polypill: The COMBO-HF-X Pilot Randomized Trial

By afschroeder • July 11, 2026

DeJong C, Durstenfeld MS, Davis JD, Wang CS, Riley ED, Huffman MD, Hickey MD, Shade SB, Chen JC, Kazi DS, Grochowski J, Steward WT, Zier LS, Sandhu AT, Heidenreich PA, Agarwal A, Hsue PY. Delivering Quadruple Therapy for Heart Failure With Reduced Ejection Fraction in a Customizable Polypill: The COMBO-HF-X Pilot Randomized Trial. JACC Heart Fail. 2026 Jul 9:103223. doi: 10.1016/j.jchf.2026.103223. Epub ahead of print. PMID: 42429718.

Tags: Adherence, Cardiology/Epi, Heart failure with reduced ejection fraction, implementation science, polypill, Publications, Veterans Administration

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