A Phase IV, Randomized, Double-Blind, Crossover Study to Compare the Clinical Safety and Efficacy of AbobotulinumtoxinA and OnabotulinumtoxinA in Adult Upper Limb Spasticity

By afschroeder • May 21, 2026

Esquenazi A, Wein TH, Verduzco-Gutierrez M, Ayyoub Z, Page S, Harding S, Maisonobe P, Beneteau M, Patel A; DIRECTION study group. A Phase IV, Randomized, Double-Blind, Crossover Study to Compare the Clinical Safety and Efficacy of AbobotulinumtoxinA and OnabotulinumtoxinA in Adult Upper Limb Spasticity. Adv Ther. 2026 May 20. doi: 10.1007/s12325-026-03635-y. Epub ahead of print. PMID: 42159955.

Tags: AbobotulinumtoxinA, Crossover study, General Internal Medicine, Head-to-head double-blind study, OnabotulinumtoxinA, Physical Medicine & Rehabilitation, Publications, safety, Upper limb spasticity

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