Transport mechanism of the SLC4 proteins – lessons from recent structural and computational studies

By afschroeder • May 17, 2026

Zhekova HR, Pushkin A, Wang W, Kao L, Tsirulnikov K, Azimov R, Abuladze N, Acuna D, Zhou ZH, Tieleman DP, Kurtz I. Transport mechanism of the SLC4 proteins - lessons from recent structural and computational studies. J Biol Chem. 2026 May 15:113092. doi: 10.1016/j.jbc.2026.113092. Epub ahead of print. PMID: 42142586.

Tags: bicarbonate transport, cryogenic electron microscopy, lipid-protein interaction, membrane protein, molecular modelling, Nephrology, protein conformation, Publications, secondary transporter, SLC4 family, structure-function, X-ray crystallography

Muscle Matters: Poor Muscle Quality Increases Mortality Risk in Early CKD

Hamdan H, Roshanravan B, Kalantar-Zadeh K. Muscle Matters: Poor Muscle Quality Increases Mortality Risk in Early CKD. Clin J Am Soc Nephrol. 2026 May 15.[...]

Hemodialysis Modality and Mortality Outcomes among Incident Dialysis Patients: An International Cohort Study Comparing High-Volume Hemodiafiltration and Hemodialysis

Zhang Y, Winter A, Ficociello LH, Arya S, Stuard S, Usvyat LA, Kalantar-Zadeh K. Hemodialysis Modality and Mortality Outcomes among Incident Dialysis Patients: An International[...]

Importance of History in the Management of New-Onset Hyperkalemia

Kagan I, Sarmosyan K, Lei S, Hwang M. Importance of History in the Management of New-Onset Hyperkalemia. Cureus. 2026 Apr 8;18(4):e106682. doi: 10.7759/cureus.106682. PMID: 42110035;[...]