Comparative analysis of NSG and NBSGW mice for preclinical evaluation of gene-modified human hematopoietic stem and progenitor cells

By afschroeder • April 17, 2026

Kuo CY, Harrington S, Campo-Fernandez B, Wyman SK, Wu X, Zhang R, Espinoza A, de Andrade Silva BJ, Sanchez JM, Fitz-Gibbon S, Tseng CH, Pellegrini M, Bonner M, Romero Z. Comparative analysis of NSG and NBSGW mice for preclinical evaluation of gene-modified human hematopoietic stem and progenitor cells. Stem Cell Res Ther. 2026 Apr 15. doi: 10.1186/s13287-026-05010-8. Epub ahead of print. PMID: 41987334.

Tags: CRISPR/Cas9, Dermatology, General Internal Medicine, Hematopoietic stem and progenitor cells (HSPCs), Humanized mouse models, Lentiviral vector (LVV), Long-term engraftment, Publications

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