p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease

By afschroeder • April 17, 2026

Salladay-Perez IA, Avila I, Estrada L, Alexandru AC, Ponce C, Dhingra A, Torres G, Deng CY, Hegde R, Gensheimer J, Kale A, Heckenbach I, Hui S, Edillor C, Soto JA, Napior AJ, Little I, Larsen M, Rose J, Farahi L, Lopez Gonzalez EDJ, Krieger MR, Chowdhury K, Sharma M, Jiang Y, Williams K, Scheibye-Knudsen M, Koehler CM, Meyer JG, Mack JJ, Brenner C, Bensinger SJ, Lagger C, de Magalhães JP, Schilling B, Singh R, Verdin E, Lusis AJ, Covarrubias AJ. p21⁺TREM2⁺ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease. Nat Aging. 2026 Apr 16. doi: 10.1038/s43587-026-01101-6. Epub ahead of print. PMID: 41991686.

Tags: Cardiology/Epi, Digestive Diseases, Post Doc, Publications

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