Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering

By afschroeder • March 20, 2026

Chen X, Mao Z, Kolawole EM, Persechino M, Jude KM, Ogishi M, Mo KC, McLaughlin J, Cheng D, Xiang X, Yang X, Gee C, Liu S, Yang A, Obenaus M, Wang N, Noguchi M, Stoyanova T, Lee JK, Good Z, Latorraca NR, Evavold BD, Witte ON, Garcia KC. Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering. Science. 2026 Mar 19;391(6791):eadx3162. doi: 10.1126/science.adx3162. Epub 2026 Mar 19. PMID: 41855322; PMCID: PMC13004167.

Tags: Hematology/Oncology, Publications

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