Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus

By afschroeder • March 15, 2026

Jiang R, Bogle R, Xing X, Kirma J, Fox J, Harms PW, Do T, Billi AC, Kahlenberg JM, Modlin RL, Teles R, West J, Mangold A, Zhang H, Schneider MA, Bruno S, Roediger B, Martiny-Baron G, Tsoi LC, Hacini-Rachinel F, Röhn TA, Gudjonsson JE. Single-cell and spatial profiling reveal cDC2A-CXCL13⁺CD8⁺ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus. Nat Commun. 2026 Mar 14. doi: 10.1038/s41467-026-70506-z. Epub ahead of print. PMID: 41832141.

Tags: Dermatology, Publications

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