In Vitro and In Vivo Evaluation of Small-Molecule Disassemblers of Pathological Tau Fibrils

By afschroeder • January 5, 2026

Pan H, Cheng X, Zhang J, Hou K, Murray KA, Manglani K, Zhu C, Hsu HK, Mekkittikul M, Halladay T, Mirbaha H, Elezi G, Abskharon R, Sawaya MR, Bombino A, Williams CK, DeTure M, Dickson DW, Vinters HV, Whitelegge JP, Harran PG, Cole GM, Frautschy SA, Eisenberg DS. In Vitro and In Vivo Evaluation of Small-Molecule Disassemblers of Pathological Tau Fibrils. ACS Chem Neurosci. 2026 Jan 4. doi: 10.1021/acschemneuro.5c00940. Epub ahead of print. PMID: 41486697.

Tags: Alzheimer’s disease, disaggregation, Geriatrics, mouse model, neurodegenerative disease, Post Doc, Publications, Small molecules, tau, Veterans Administration

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