The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors

Agirman G, Quicho MNB, Connelley KK, Zhang X, Lynch JB, Ha SM, Schmidt HM, Özcan E, Liang AX, Yu KB, Ahn IS, Qian C, Paramo J, Zhang S, Espinoza A, Turnbaugh PJ, de Aguiar Vallim TQ, Yang X, Church A, Hsiao EY. The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors. Cell Host Microbe. 2025 Nov 25:S1931-3128(25)00453-6. doi: 10.1016/j.chom.2025.10.019. Epub ahead of print. PMID: 41297540.


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