Targeting orthotopic and metastatic pancreatic cancer with allogeneic stem cell-engineered mesothelin-redirected CAR-NKT cells

By afschroeder • November 22, 2025

Li YR, Shen X, Zhu E, Li Z, Huang J, Le T, Tran C, Radu CG, Yang L. Targeting orthotopic and metastatic pancreatic cancer with allogeneic stem cell-engineered mesothelin-redirected CAR-NKT cells. Proc Natl Acad Sci U S A. 2025 Nov 25;122(47):e2517786122. doi: 10.1073/pnas.2517786122. Epub 2025 Nov 21. PMID: 41269799.

Tags: Allogeneic cell therapy, Cardiology/Epi, chimeric antigen receptor (CAR), invariant natural killer T (NKT) cell, metastatic cancer, Pancreatic cancer (PC), Publications, Veterans Administration

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