Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors

By afschroeder • November 2, 2025

Wu M, Yang S, Yang Z, Fan J, Lomeli SH, Dharanipragada P, Moriceau G, Damoiseaux R, Kelley MC, Prieto-Granada CN, Giubellino A, Nosrati M, Kashani-Sabet M, Kim KB, Johnson DB, Liu S, Lo RS. Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors. Immunity. 2025 Oct 31:S1074-7613(25)00431-5. doi: 10.1016/j.immuni.2025.10.001. Epub ahead of print. PMID: 41175874.

Tags: acquired resistance, Anti-CTLA-4, Anti-PD-1, apoptosis sensitivity, copy-number variation, Dermatology, genomic evolution, immune checkpoint inhibitor, immune evasion, melanoma, Post Doc, Publications, single-cell whole-genome sequencing, T cell cytotoxicity, whole-exome sequencing

The Colors Beneath: More Than a Skin Condition

Yan MJ, Chou PP, Roberts AM, Jeong CY, Johnsen N, Katz A, Ma EJ, Nong Y, Armstrong AW. The Colors Beneath: More Than a Skin[...]

Adjuvant therapy of severe and/or refractory bullous pemphigoid with immunoadsorption – A prospective monocenter pilot study

Holtsche MM, van Beek N, Hammers CM, Vorobyev A, Kasperkiewicz M, Schumacher N, Muck P, Schmidt E. Adjuvant therapy of severe and/or refractory bullous pemphigoid[...]

Retraction Note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R,[...]