Altered Sigmoid Mucosal Innervation and Mast Cell Proximity to Sensory Nerve Fibers Are Associated With Symptom Severity in Patients With Irritable Bowel Syndrome

By afschroeder • November 3, 2025

Yuan PQ, Nash M, Li T, Mahurkar-Joshi S, Sohn J, Khandadash A, Taché Y, Chang L. Altered Sigmoid Mucosal Innervation and Mast Cell Proximity to Sensory Nerve Fibers Are Associated With Symptom Severity in Patients With Irritable Bowel Syndrome. Neurogastroenterol Motil. 2025 Nov 2:e70199. doi: 10.1111/nmo.70199. Epub ahead of print. PMID: 41177834.

Tags: abdominal pain, Digestive Diseases, enteric cholinergic fibers, General Internal Medicine, Irritable Bowel Syndrome, Mast cells, Publications, Resident, substance P, vasoactive intestinal peptide

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