Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery

By afschroeder • October 2, 2025

Murad JP, Christian L, Rosa R, Ren Y, Buckley AJ, Lee EHJ, Lopez LS, Park AK, Yang J, Yamaguchi Y, Trac C, Adkins LN, Chang WC, Martinez C, June CH, Forman SJ, Ishihara J, Lee JK, Stern LA, Priceman SJ. Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery. Nat Biomed Eng. 2025 Oct 1. doi: 10.1038/s41551-025-01509-2. Epub ahead of print. PMID: 41034514.

Tags: Hematology/Oncology, Publications

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