Trimethylamine- N-Oxide Affects Cell Type-Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability

By afschroeder • September 25, 2025

Cheng J, Cheng M, Sinha S, Cely I, Gladkikh S, Han MT, Zhang G, Zhou Z, Chugh R, Ahn IS, Diamante G, Wang YC, Wang Z, Bennett BJ, Cai H, Allayee H, Hazen SL, Lusis AJ, Shih DM, Yang X. Trimethylamine-N-Oxide Affects Cell Type-Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability. Arterioscler Thromb Vasc Biol. 2025 Oct;45(10):1784-1798. doi: 10.1161/ATVBAHA.125.323047. Epub 2025 Aug 14. PMID: 40808653; PMCID: PMC12453107.

Tags: aorta, Atherosclerosis, atherosclerotic, Cardiology/Epi, Gene regulatory networks, mice, Nephrology, plaque, Publications, single-cell RNA-sequencing, TMAO

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