PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity

By afschroeder • September 6, 2025

Yang S, Santelli E, Gonzalez CG, Johnson WT, Choi IV, Zhuang C, Ro M, Rossitto LM, Yu IS, Lin SW, Zhan Y, Chen Q, Yoshihara JD, Wallace DJ, Jefferies CA, Yamashita M, Gonzalez DJ, Ainsworth RI, Shah NJ, Stanford SM, Bottini N. PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity. Sci Adv. 2025 Sep 5;11(36):eadw2568. doi: 10.1126/sciadv.adw2568. Epub 2025 Sep 5. PMID: 40911684; PMCID: PMC12412669.

Tags: Cedars Sinai DoM, Publications, Rheumatology

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