Rucaparib for maintenance treatment of platinum-sensitive, recurrent ovarian carcinoma: Final results of the phase 3, randomized, placebo-controlled ARIEL3 trial

By sjmartinez • July 1, 2025

Ledermann JA, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp AR, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Banerjee S, García-Donas J, Swisher EM, Lebreton C, Konecny GE, McNeish IA, Scott CL, Maloney L, Goble S, Lin KK, Coleman RL. Rucaparib for maintenance treatment of platinum-sensitive, recurrent ovarian carcinoma: Final results of the phase 3, randomized, placebo-controlled ARIEL3 trial. Eur J Cancer. 2025 Jun 17;225:115584. doi: 10.1016/j.ejca.2025.115584. Epub ahead of print. PMID: 40580808.

Tags: ADP-ribose, BRCA, Hematology/Oncology, Homologous recombination deficient, Long-term follow-up, overall survival, PFS2, Poly polymerase inhibitor, Progression-free interval, Publications, Recurrent ovarian cancer

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