Galectin-1 modulates glycolysis via a GM1-galactose-dependent pathway to promote hyperthermia resistance in hepatocellular carcinoma

By sjmartinez • May 23, 2025

Nguyen T, Shin Y, Ruppa A, Krall AS, Pham J, Chen PC, Mirmohammadi H, Keshavarz P, Finn RS, Agopian VG, French SW, Christofk HR, Lu DSK, Raman SS, Chiang J. Galectin-1 modulates glycolysis via a GM1-galactose-dependent pathway to promote hyperthermia resistance in hepatocellular carcinoma. Hepatology. 2025 May 21. doi: 10.1097/HEP.0000000000001391. Epub ahead of print. PMID: 40403181.

Tags: GM1-ganglioside, Hematology/Oncology, leloir pathway, liver cancer recurrence, Publications, TCA cycle, Thermal-ablation

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