Human leukocyte antigen class I antibody-activated endothelium promotes CD206+ M2 macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy

By sjmartinez • February 22, 2024

Nevarez-Mejia J, Jin YP, Pickering H, Parmar R, Valenzuela NM, Sosa RA, Heidt S, Fishbein GA, Rozengurt E, Baldwin WM 3rd, Fairchild RL, Reed EF. Human leukocyte antigen class I antibody-activated endothelium promotes CD206+ M2 macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy. Am J Transplant. 2023 Oct 29:S1600-6135(23)00822-5. doi: 10.1016/j.ajt.2023.10.020. Epub ahead of print. PMID: 38379280.

Tags: AMR, antibody-mediated rejection, AOIs, areas of interest, cardiac allograft vasculopathy, CAV, Digestive Diseases, donor-specific HLA antibodies, DSA, EC, endothelial cell, HLA, human leukocyte antigen, Publications, transplant vasculopathy, TV

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