Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity

By sjmartinez • April 20, 2023

Heyden KE, Fiddler JL, Xiu Y, Malysheva OV, Handzlik MK, Phinney WN, Stiles L, Stabler SP, Metallo CM, Caudill MA, Field MS. Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity. PNAS Nexus. 2023 Mar 27;2(4):pgad105. doi: 10.1093/pnasnexus/pgad105. PMID: 37077889; PMCID: PMC10109189.

Tags: DNA, Endocrinology, folate, methionine synthase, Publications, uracil, vitamin B12

The ULK1-NCOA3 axis restrains de novo lipogenesis and prevents diet-induced steatohepatitis and fibrosis in mice

Koo YD, Castillo RT, Sukumaran Nair A, Garneau M, Gochee C, Campbell ZV, Vakil TS, Ha J, Marti A, Soto J, Das D, Martinez-Lopez N,[...]

Omitting Radioactive Iodine after Therapeutic Lateral Neck Dissection May Be the Next Step in De-Escalating Initial Treatment of Papillary Thyroid Cancer

Yeh MW. Omitting Radioactive Iodine after Therapeutic Lateral Neck Dissection May Be the Next Step in De-Escalating Initial Treatment of Papillary Thyroid Cancer. Thyroid. 2026[...]

Knowledge of Interpreter Rights and Medication Delays in Diabetes Care

Linares MA, Everett EM, Rodriguez JA, Casillas A, Brown A. Knowledge of Interpreter Rights and Medication Delays in Diabetes Care. J Immigr Minor Health. 2026[...]