Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing

By sjmartinez • March 22, 2023

McAuley GE, Yiu G, Chang PC, Newby GA, Campo-Fernandez B, Fitz-Gibbon ST, Wu X, Kang SL, Garibay A, Butler J, Christian V, Wong RL, Everette KA, Azzun A, Gelfer H, Seet CS, Narendran A, Murguia-Favela L, Romero Z, Wright N, Liu DR, Crooks GM, Kohn DB. Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing. Cell. 2023 Mar 15:S0092-8674(23)00170-8. doi: 10.1016/j.cell.2023.02.027. Epub ahead of print. PMID: 36944331.

Tags: artificial thymic organoid, base editing, CD3D severe combined immune deficiency, CITE-seq, Hematology/Oncology, hematopoietic stem and progenitor cells, Publications, Rheumatology

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