Single-cell profiling reveals monocyte mitochondrial dysfunction in patients with cirrhosis progressing to acute-on-chronic liver failure

By afschroeder • November 4, 2026

Wirtz TH, Palomino-Echeverria S, Pollmanns MR, Huergo E, Schreibing F, Reißing J, Sánchez-Garrido C, López-Vicario C, Aransay AM, Baldassare M, Zaccherini G, Pompili E, McCoy MS, Uschner FE, Klein S, Gu W, Schierwagen R, Valainathan S, Verbeeck A, Campion D, Giovo I, Schneider KM, Koch A, Kramann R, Bruns T, Kiani N, Stiles L, Caraceni P, Alessandria C, Moreau R, Trebicka J, Clària J, Planell N, Rautou PE, Trautwein C, Gomez-Cabrero D. Single-cell profiling reveals monocyte mitochondrial dysfunction in patients with cirrhosis progressing to acute-on-chronic liver failure. JHEP Rep. 2026 Nov 3:102087. doi: 10.1016/j.jhepr.2026.102087. Epub ahead of print. PMID: 42977219.

Tags: acute decompensation, Bioenergetics, Endocrinology, immune dysfunction, Oxidative phosphorylation, Publications

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